BDBM50323212 6-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxy-phenyl)-chromen-4-one::CHEMBL63677::ROBUSTAFLAVONE

SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)c(c(O)cc2o1)-c1cc(ccc1O)-c1cc(O)c2c(cc(O)cc2=O)o1

InChI Key InChIKey=ZGYUPHWIDDUUKZ-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50323212   

TargetBeta-secretase 1(Human)
Shujitsu University

Curated by ChEMBL
LigandPNGBDBM50323212(CHEMBL63677 | 6-[5-(5,7-Dihydroxy-4-oxo-4H-chromen...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BACE1 after 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Catholic University of Daegu

Curated by ChEMBL
LigandPNGBDBM50323212(CHEMBL63677 | 6-[5-(5,7-Dihydroxy-4-oxo-4H-chromen...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human recombinant PTP1B using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50323212(CHEMBL63677 | 6-[5-(5,7-Dihydroxy-4-oxo-4H-chromen...)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of recombinant human MMP9 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50323212(CHEMBL63677 | 6-[5-(5,7-Dihydroxy-4-oxo-4H-chromen...)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of recombinant human MMP2 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50323212(CHEMBL63677 | 6-[5-(5,7-Dihydroxy-4-oxo-4H-chromen...)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of human neutrophil elastase using N-Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilid as substrate measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Medichem Research

Curated by ChEMBL
LigandPNGBDBM50323212(CHEMBL63677 | 6-[5-(5,7-Dihydroxy-4-oxo-4H-chromen...)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of HIV1 recombinant reverse transcriptase p66/p51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetGenome polyprotein(Dengue virus)
Csir-Indian Institute of Chemical Technology (CSIR-IICT)

Curated by ChEMBL
LigandPNGBDBM50323212(CHEMBL63677 | 6-[5-(5,7-Dihydroxy-4-oxo-4H-chromen...)
Affinity DataIC50: 330nMAssay Description:Inhibition of DENV C-terminal histidine-tagged NS5/RNA-dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Catholic University of Daegu

Curated by ChEMBL
LigandPNGBDBM50323212(CHEMBL63677 | 6-[5-(5,7-Dihydroxy-4-oxo-4H-chromen...)
Affinity DataKi:  6.80E+3nMAssay Description:Mixed-competitive inhibition of human recombinant PTP1B using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed