BDBM50316253 CHEMBL1095627::tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(N)cc1)N1CCOCC1

InChI Key InChIKey=OHKRUKRKVNWNNT-UHFFFAOYSA-N

Data  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50316253   

TargetTyrosine-protein kinase Lyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of LYN AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of ATR by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 495nMAssay Description:Inhibition of PI3Kgamma by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 41nMAssay Description:Inhibition of PI3Kalpha by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of RSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform gamma-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CK1gamma1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 4.51E+4nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IKKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed