BDBM50314344 4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzamide::CHEMBL1092754

SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)NCCO

InChI Key InChIKey=YDELNSXADYPQGS-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50314344   

TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 50nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 2.71E+4nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cMetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 11nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 46nMAssay Description:Inhibition of RSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 50nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 36nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 50nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 28nMAssay Description:Inhibition of LYN AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 50nMAssay Description:Inhibition of P38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 50nMAssay Description:Inhibition of IKKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 39nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314344(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Affinity DataIC50: 2.22E+4nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed