BDBM50314073 3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide::3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl}-N,4-dimethylbenzamide::CHEMBL1088751::D3RKN_8::PH-797804::PHA-797804

SMILES Cc1ccc(cc1N2C(=CC(=C(C2=O)Br)OCc3ccc(cc3F)F)C)C(=O)NC

InChI Key InChIKey=KCAJXIDMCNPGHZ-UHFFFAOYSA-N

Data  4 KI  7 IC50  4 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50314073   

TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of p38alpha kinase in human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of p38alpha kinase-dependent HSP-27 phosphorylation in human U937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataKd:  2.5nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells assessed as dissociation rate consta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2022More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataKi:  5.80nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataKi:  40nMAssay Description:Inhibition of p38beta kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataKi: >4.00E+5nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed