BDBM50314070 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL1090089::pamapimod

SMILES CN1c2c(cnc(n2)NC(CCO)CCO)C=C(C1=O)Oc3ccc(cc3F)F

InChI Key InChIKey=JYYLVUFNAHSSFE-UHFFFAOYSA-N

Data  8 IC50  20 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50314070   

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  190nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  1.30nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase 36(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of STK36More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-4(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  150nMAssay Description:Inhibition of RSK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  300nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  170nMAssay Description:Inhibition of NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  19nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  16nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-G-associated kinase(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of GAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of DDR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  260nMAssay Description:Inhibition of CSNK1epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAtypical kinase COQ8A, mitochondrial(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of ADCK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  120nMAssay Description:Inhibition of P38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform epsilon(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  260nMAssay Description:Binding affinity to CSNK1epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  190nMAssay Description:Binding affinity to JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  170nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  19nMAssay Description:Binding affinity to JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  16nMAssay Description:Binding affinity to JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  120nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataIC50: 5.42E+3nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed