BDBM50313524 3,5-dioxo-4-(3-(piperidin-1-yl)propyl)-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile::3,5-dioxo-4-(3-piperidin-1-ylpropyl)-2-[3-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile::CHEMBL1084114

SMILES c1cc(cc(c1)N2C(=O)N(C(=O)C(=N2)C#N)CCCN3CCCCC3)C(F)(F)F

InChI Key InChIKey=HKAVWQNLXOMWLR-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50313524   

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313524(3,5-dioxo-4-(3-piperidin-1-ylpropyl)-2-[3-(trifluo...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin B(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313524(3,5-dioxo-4-(3-piperidin-1-ylpropyl)-2-[3-(trifluo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313524(3,5-dioxo-4-(3-piperidin-1-ylpropyl)-2-[3-(trifluo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313524(3,5-dioxo-4-(3-piperidin-1-ylpropyl)-2-[3-(trifluo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed