BDBM50312990 (R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione::CHEMBL1082152

SMILES Cn1cc(c2c1ccc(c2)F)C3=C(C(=O)NC3=O)c4cccc(c4)NC[C@@H](CO)O

InChI Key InChIKey=RPGZQOOZHIEPJW-UHFFFAOYSA-N

Data  1 IC50  33 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50312990   

TargetCyclin-dependent kinase 17(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  69nMAssay Description:Inhibition of PCTK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  320nMAssay Description:Inhibition of PLK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  310nMAssay Description:Inhibition of CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 16(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  230nMAssay Description:Inhibition of STK16More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  150nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 18 [3-474](Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  110nMAssay Description:Inhibition of PCTK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  110nMAssay Description:Inhibition of CLK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  87nMAssay Description:Inhibition of DYRK1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  80nMAssay Description:Inhibition of CDK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  410nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  41nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 15(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  32nMAssay Description:Inhibition of ERK8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  16nMAssay Description:Inhibition of CLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 16(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  12nMAssay Description:Inhibition of PCTK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  10nMAssay Description:Inhibition of CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  1.5nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  0.0530nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 6(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  4.00E+4nMAssay Description:Inhibition of ERK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataIC50: 400nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  4.00E+4nMAssay Description:Inhibition of AURKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  4.00E+4nMAssay Description:Inhibition of CDK8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 4(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  4.00E+4nMAssay Description:Inhibition of ERK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  4.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  4.00E+4nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 19(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  4.00E+4nMAssay Description:Inhibition of CDK11More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  4.00E+4nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  0.0530nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  4.00E+4nMAssay Description:Inhibition of AURKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  2.30E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  2.30E+4nMAssay Description:Inhibition of AURKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  1.40E+4nMAssay Description:Inhibition of PRKRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  6.80E+3nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  6.70E+3nMAssay Description:Inhibition of TTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  5.60E+3nMAssay Description:Inhibition of ERK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed