BDBM50311045 3-bromo-10-(difluoromethyl)-9H-benzo[f]imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine::CHEMBL1080588::Ro-4938581

SMILES FC(F)c1ncn-2c1Cn1ncnc1-c1cc(Br)ccc-21

InChI Key InChIKey=AFJRYPJIKHMNGL-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50311045   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50311045(Ro-4938581 | 3-bromo-10-(difluoromethyl)-9H-benzo[...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]Flumazenil from cloned human GABA alpha-5-beta-3-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50311045(Ro-4938581 | 3-bromo-10-(difluoromethyl)-9H-benzo[...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to GABA-A alpha5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50311045(Ro-4938581 | 3-bromo-10-(difluoromethyl)-9H-benzo[...)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]Flumazenil from cloned human GABA alpha-3-beta-3-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50311045(Ro-4938581 | 3-bromo-10-(difluoromethyl)-9H-benzo[...)
Affinity DataKi:  80nMAssay Description:Binding affinity to GABA-A alpha3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50311045(Ro-4938581 | 3-bromo-10-(difluoromethyl)-9H-benzo[...)
Affinity DataKi:  174nMAssay Description:Displacement of [3H]Flumazenil from cloned human GABA alpha-1-beta-3-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50311045(Ro-4938581 | 3-bromo-10-(difluoromethyl)-9H-benzo[...)
Affinity DataKi:  174nMAssay Description:Binding affinity to GABA-A alpha1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50311045(Ro-4938581 | 3-bromo-10-(difluoromethyl)-9H-benzo[...)
Affinity DataKi:  185nMAssay Description:Displacement of [3H]Flumazenil from cloned human GABA alpha-2-beta-3-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50311045(Ro-4938581 | 3-bromo-10-(difluoromethyl)-9H-benzo[...)
Affinity DataKi:  185nMAssay Description:Binding affinity to GABA-A alpha2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed