BDBM50307507 CHEMBL597754::N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

SMILES CNC(=O)c1nn(C)c-2c1CCc1cnc(NC3CCN(CC3)C(=O)C3CCN(CC3)S(C)(=O)=O)nc-21

InChI Key InChIKey=KOLSEKSFVMGHDV-UHFFFAOYSA-N

Data  47 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 47 hits for monomerid = 50307507   

LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 26(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MST4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NEK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BUB1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 622nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 176nMAssay Description:Inhibition of CDK4/Cyclin D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CDK2/Cyclin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK5/P25More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 358nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ACK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetEukaryotic elongation factor 2 kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EEF2KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed