BDBM50306684 2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide::CHEMBL602472

SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl

InChI Key InChIKey=QACCVOJRKKIYFM-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50306684   

TargetEpidermal growth factor receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant EGFR by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 430nMAssay Description:Inhibition of recombinant AXL by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of recombinant EphA2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant LTK by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant FGFR2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant Flt3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant Fyn by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of recombinant IGF1R by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of recombinant LCK by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of recombinant Kit by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant PKCalpha by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant YES by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant BRK by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant Abl by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of recombinant Aurora A by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant AKT1 by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant CDK1 by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant CDK2 by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant RON by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant InsR by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed