BDBM50305074 4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8-(trifluoromethyl)quinoline::4-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)quinoline::CHEMBL593241

SMILES CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2ccnc3c(cccc23)C(F)(F)F)c1

InChI Key InChIKey=DZEKZLIXNYUATR-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50305074   

TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305074(4-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluo...)
Affinity DataIC50: 40nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRbeta-LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305074(4-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluo...)
Affinity DataIC50: 2.80nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50305074(4-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluo...)
Affinity DataEC50:  5.96E+3nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50305074(4-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluo...)
Affinity DataEC50:  2.94E+3nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed