BDBM50303760 (R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL571319

SMILES CN1C(=O)[C@](N=C1N)(c2ccc(cc2)OC)C34CC5CC(C3)CC(C5)C4

InChI Key InChIKey=BGCGXOOJJMGOQV-UHFFFAOYSA-N

Data  1 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303760   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303760((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303760((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataIC50: 2.08E+4nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50303760((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataEC50:  16nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50303760((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataEC50:  4.60E+3nMAssay Description:Inhibition of PRMT5 in human MCF7 cells assessed as reduction in symmetrically dimethylated nuclear protein level incubated for 3 days by Alexafluor-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)