BDBM50303591 1-(4-(6-aminoquinolin-4-ylamino)phenyl)-3-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)urea::1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea::CHEMBL570904

SMILES Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(Nc2ccnc3ccc(N)cc23)cc1)C(C)(C)C

InChI Key InChIKey=MKHUGLZLKVCOGF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303591   

TargetMitogen-activated protein kinase 14(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303591(1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-ter...)
Affinity DataIC50: 900nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303591(1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-ter...)
Affinity DataIC50: 100nMAssay Description:Displacement of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylurei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303591(1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-ter...)
Affinity DataIC50: 380nMAssay Description:Inhibition of JNK2 active form by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303591(1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-ter...)
Affinity DataIC50: 470nMAssay Description:Displacement of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylurei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed