BDBM50300026 (S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl]pyrrolidine-2-carboxamide::CHEMBL571040

SMILES COCCOc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1NC(=O)[C@@H]1CCCN1C(=O)C=C

InChI Key InChIKey=TXSZGBMOPCXBTP-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50300026   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Raf1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Flt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of Flt4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 800nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 700nMAssay Description:Inhibition of RetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 500nMAssay Description:Inhibition of Abl1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 300nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 42nMAssay Description:Inhibition of Her2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Her1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Hanmi Research Center

Curated by ChEMBL
LigandPNGBDBM50300026((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Her4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed