BDBM50278349 2-(Diphenylboryloxy)Ethanamine::2-Aminoethoxydiphenyl Borate::CHEMBL169233

SMILES B(c1ccccc1)(c2ccccc2)OCCN

InChI Key InChIKey=BLZVCIGGICSWIG-UHFFFAOYSA-N

Data  6 IC50  1 EC50

PDB links: 13 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50278349   

TargetTransient receptor potential cation channel subfamily M member 2(Human)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux by whole cell patch clamp electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataEC50:  1.29E+5nMAssay Description:Agonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as induction of Ca2+ levels by Fuo-4-AM based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Chemistry and Technology Prague

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of rabbit skeletal muscle microsomes FITC-labelled SERCA1a incubated for 1 hr by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 2(Human)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 2(Human)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current by whole cell patch-clamp m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 2(Human)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 7(Mouse)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of FLAG-tagged mouse TRPM7 transfected in HEK293 cells assessed as inhibition of channel-mediated Mn2+ influx incubated for ~15 mins and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed