BDBM50274586 CHEMBL4128181

SMILES CN(C)C(=O)C(=Cc1ccc(o1)c2nc3cnc4c(c3n2C5CCCCC5)cc[nH]4)C#N

InChI Key InChIKey=GJMZWYLOARVASY-UHFFFAOYSA-N

Data  10 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50274586   

TargetTyrosine-protein kinase JAK2(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of kinase tracer-05 binding to C-terminal NanoLuc tagged full length JAK2 (unknown origin) expressed in HEK cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataEC50:  237nMAssay Description:Inhibition of kinase tracer-05 binding to C-terminal NanoLuc tagged full length JAK3 (unknown origin) expressed in HEK cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of kinase tracer-05 binding to C-terminal NanoLuc tagged full length BTK (unknown origin) expressed in HEK cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of kinase tracer-04 binding to C-terminal NanoLuc tagged full length JAK1 (unknown origin) expressed in HEK cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataIC50: 3.46E+3nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] (4:1) as substrate in presence of 200 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataIC50: 2nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of 200 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataIC50: 459nMAssay Description:Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataIC50: 668nMAssay Description:Inhibition of human JAK1 using poly[Glu:Tyr] (4:1) as substrate in presence of 200 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of 200 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human JAK3 (781 to 1124 residues) expressed in baculovirus expression system assessed as reduction in polypeptide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataIC50: 52nMAssay Description:Inhibition of human JAK1 using poly[Glu:Tyr] (4:1) as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataIC50: 346nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] (4:1) as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50274586(CHEMBL4128181)
Affinity DataIC50: 9nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 1 hr in presence of ATP and substrate by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed