BDBM50269850 CHEMBL4061600

SMILES CC(=O)N1CCc2c(c(nn2[C@H]3CCOC3)N4CCCc5c4cc(c(c5)c6cnn(c6)C)C(F)F)C1

InChI Key InChIKey=FLTYKXCCCAPRLV-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50269850   

TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50269850(CHEMBL4061600)
Affinity DataIC50: 37nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to NanoLuc luciferase conjugated human CBP expressed in HEK293 cells after overnight incubation by BRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50269850(CHEMBL4061600)
Affinity DataIC50: 5.60E+3nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged BRD4 bromodomain-1 measured after 10 mins by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50269850(CHEMBL4061600)
Affinity DataIC50: 1.40nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)