BDBM50269558 CHEMBL4077588

SMILES Nc1nccn2c(nc(-c3ccc(cc3F)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CCCN(C1)C1CCOCC1

InChI Key InChIKey=LSJWYMSFUWBGPN-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50269558   

LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 100nMAssay Description:Inhibition of human ERG by [35S]-MK499 displacement or iKr channel assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 50nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 231nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 77nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 48nMAssay Description:Inhibition of PTK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 170nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 105nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 32nMAssay Description:Inhibition of YES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 65nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in anti-IgM-induced MIP1betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 7nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 127nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 29nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase FRK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 85nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 22nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 59nMAssay Description:Inhibition of ERBB4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 455nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 115nMAssay Description:Inhibition of LYNB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant full-length His6-tagged BTK (unknown origin) expressed in baculovirus infected Sf9 cells using biotinylated A5 peptide as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed