BDBM50265965 CHEMBL4061051

SMILES Cn1c(ccn1)Nc2nccc(n2)c3cc4c(n3C)CCN(C4=O)CCOC

InChI Key InChIKey=YREPJIXZZKOVIM-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50265965   

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265965(CHEMBL4061051)
Affinity DataIC50: 23nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 60 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50265965(CHEMBL4061051)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265965(CHEMBL4061051)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated RSK levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265965(CHEMBL4061051)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated ERK2 levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265965(CHEMBL4061051)
Affinity DataIC50: 240nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)