BDBM50260029 CHEMBL4088388::US10370360, Example 40

SMILES C[C@H]1CN(Cc2c1ccc(c2)NC(=O)c3cc(cc(c3)C(F)(F)F)CN4CCN(CC4)C)c5cncnc5

InChI Key InChIKey=FXWGWJNBGHQODS-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50260029   

TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged c-kit cytoplasmic domain (544 to 976 residues) expressed in baculovirus expression system using Ser/Thr 6 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2020
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human GST-tagged DDR2 cytoplasmic domain expressed in baculovirus expression system using Fluorescein-Poly GAT as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2020
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: 76nMAssay Description:Inhibition of recombinant human GST-tagged DDR1 catalytic domain expressed in baculovirus expression system using Fluorescein-Poly GAT as substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpithelial discoidin domain-containing receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: 66.2nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDiscoidin domain-containing receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: 1.40E+3nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of Texas

US Patent
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: 1.00E+4nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: 1.00E+4nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of Texas

US Patent
LigandPNGBDBM50260029(CHEMBL4088388 | US10370360, Example 40)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length His-tagged Bcr-Abl fusion protein cytoplasmic domain expressed in baculovirus expression system using tyr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2020
Entry Details Article
PubMed