BDBM50259131 CHEMBL466517::JNJ-26990990::N-((Benzo[b]thien-3-yl)methyl)sulfamide::N-(1-benzothien-3-ylmethyl)sulfamide

SMILES c1ccc2c(c1)c(cs2)CNS(=O)(=O)N

InChI Key InChIKey=AWSKBQNOSRREEY-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50259131   

TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 2 subunit alpha(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of rat Cav2.2 channel expressed in 0.07 Hz frequency-stimulated HEK cells by whole-cell patch-clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of carbonic anhydrase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)