BDBM50258424 CHEMBL494221::trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-ylamino)cyclohexanol

SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2n1

InChI Key InChIKey=DJIOCMRPQBSLOC-UHFFFAOYSA-N

Data  18 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50258424   

TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi:  230nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of MAP3K7More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of ITKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of COTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258424(trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed