BDBM50258287 CHEMBL493169::N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine

SMILES FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CCNCC3)nn12

InChI Key InChIKey=SENFEQVLOFSJFU-UHFFFAOYSA-N

Data  17 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50258287   

TargetSerine/threonine-protein kinase pim-1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi:  21nMAssay Description:Inhibition of Pim1 assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi:  800nMAssay Description:Inhibition of Aurora 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of ITKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed