BDBM50250927 CHEMBL4071005::US10766883, Ex-1

SMILES COc1cc(ccc1Cl)Nc2c(cn(n2)[C@H]3COCC[C@@H]3C#N)C(=O)N

InChI Key InChIKey=MFWQXZZXOUIDTN-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50250927   

TargetTyrosine-protein kinase JAK3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 397nMAssay Description:Inhibition of GST-tagged recombinant human JAK3 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human TYK2 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of GST-tagged recombinant human JAK1 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of JAK2 in EPO-stimulated human TF1 cells expressing stably integrated beta-lactamase reporter gene under control of STAT5 response elemen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of JAK1 in human whole blood assessed as decrease in cytokine-stimulated STAT phosphorylation preincubated for 20 mins followed by cytokin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 320nMAssay Description:Inhibition of JAK2 in EPO-stimulated human TF1 cells expressing stably integrated beta-lactamase reporter gene under control of STAT5 response elemen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 13nMAssay Description:Inhibition of JAK1 in IL6-stimulated human ME180 cells expressing stably integrated beta-lactamase reporter gene under control of sis-inducible eleme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 0.120nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 3.88nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent