BDBM50246774 3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyrrolo[3',4':2,3][1,4]diazepino[1,7-a]indol-2-yl)propyl Imidothiocarbamate::CHEMBL489083

SMILES NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O

InChI Key InChIKey=RUTCIZOQGCWURK-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50246774   

TargetVascular endothelial growth factor receptor 3(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human INSRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human CDK2/Cyc2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human CDK4/CycD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of human PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of human ERBB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Institute of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246774(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human AXLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed