BDBM50246327 4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-N-methylbenzenesulfonamide::4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide::CHEMBL509485

SMILES CNS(=O)(=O)c1ccc(Nc2ncc(c(N[C@@H]3CCC[C@H]3N(C)C)n2)C(F)(F)F)cc1

InChI Key InChIKey=CAUFYHKGKDJMQG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50246327   

TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino...)
Affinity DataIC50: 154nMAssay Description:Inhibition of GST-tagged pyk2 assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylation by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino...)
Affinity DataIC50: 140nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphorylation by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino...)
Affinity DataIC50: 88nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed