BDBM50244569 AP24283::CHEMBL510893::N-(4-(dimethylphosphoryl)phenyl)-9-(2-(5-methyl-1H-indazol-4-yl)vinyl)-9H-purin-6-amine::N-[4-(dimethylphosphoryl)phenyl]-9-[(E)-2-(5-methyl-1H-indazol-4-yl)ethenyl]-9H-purin-6-amine

SMILES Cc1ccc2[nH]ncc2c1\C=C\n1cnc2c(Nc3ccc(cc3)P(C)(C)=O)ncnc12

InChI Key InChIKey=UNPSONVHRMUXFE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50244569   

TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

LigandPNGBDBM50244569(CHEMBL510893 | AP24283 | N-[4-(dimethylphosphoryl)...)
Affinity DataIC50: 0.5nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1 [T315I](Human)
Ariad Pharmaceuticals

LigandPNGBDBM50244569(CHEMBL510893 | AP24283 | N-[4-(dimethylphosphoryl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2011
Entry Details Article
PubMed
TargetIsoform 1 of Fibronectin (1)(Human)
Ariad Pharmaceuticals

LigandPNGBDBM50244569(CHEMBL510893 | AP24283 | N-[4-(dimethylphosphoryl)...)
Affinity DataIC50: 0.5nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

LigandPNGBDBM50244569(CHEMBL510893 | AP24283 | N-[4-(dimethylphosphoryl)...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244569(CHEMBL510893 | AP24283 | N-[4-(dimethylphosphoryl)...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed