BDBM50243182 CHEMBL487431::N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide::N3-(6-aminopyridin-3-yl)-N1-(2-cyclopentylethyl)-4-methylisophthalamide

SMILES Cc1ccc(cc1C(=O)Nc2ccc(nc2)N)C(=O)NCCC3CCCC3

InChI Key InChIKey=CLEGTVIMOPPIBR-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50243182   

LigandPNGBDBM50243182(N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of c-Kit by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243182(N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDR by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243182(N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of Lck by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243182(N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Src by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243182(N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243182(N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-...)
Affinity DataIC50: 998nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243182(N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed