BDBM50242360 CHEMBL4069575

SMILES CCc1cc2ccc1CCOC(=O)Nc3ccc(c(c3)CN(C(=O)[C@@H]2Nc4cccc(c4)C(=O)N)C)S(=O)(=O)C(C)C

InChI Key InChIKey=KZSYSYPLRUUKEU-UHFFFAOYSA-N

Data  10 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50242360   

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50242360(CHEMBL4069575)
Affinity DataKi:  610nMAssay Description:Inhibition of tissue factor activated recombinant human coagulation factor 7a expressed in hamster BHK cells using S2288 as substrate pretreated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor VII(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50242360(CHEMBL4069575)
Affinity DataKi:  610nMAssay Description:Inhibition of tissue factor activated recombinant human coagulation factor 7a expressed in hamster BHK cells using S2288 as substrate pretreated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKallikrein-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50242360(CHEMBL4069575)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of Tissue Kallikrein (unknown origin) using H-D-Val-Leu-Arg-AFC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50242360(CHEMBL4069575)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibition of tissue factor/factor 7a activated human coagulation factor-10a using S2765 as substrate pretreated with substrate for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50242360(CHEMBL4069575)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of plasma kallikrein (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed
TargetPlasminogen(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50242360(CHEMBL4069575)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of plasmin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50242360(CHEMBL4069575)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50242360(CHEMBL4069575)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of urokinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50242360(CHEMBL4069575)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of TPA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50242360(CHEMBL4069575)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of activated protein C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed