BDBM50241202 2-Methyl-3H-quinazolin-4-one::CHEMBL395092

SMILES CC1=Nc2ccccc2C(=O)N1

InChI Key InChIKey=FIEYHAAMDAPVCH-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50241202   

TargetPoly [ADP-ribose] polymerase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50241202(2-Methyl-3H-quinazolin-4-one | CHEMBL395092)
Affinity DataIC50: 5.60E+3nMAssay Description:The compound was tested for poly(ADP-ribose)-polymerase (PARP) inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50241202(2-Methyl-3H-quinazolin-4-one | CHEMBL395092)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of PARP1 using TACS-Sapphire substrate for 30 mins by colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50241202(2-Methyl-3H-quinazolin-4-one | CHEMBL395092)
Affinity DataKi:  9.90E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PDE10A2 catalytic domain expressed in Escherichia coli BL21(DE3) RIL cells using 3',5'-cGMP as substrate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50241202(2-Methyl-3H-quinazolin-4-one | CHEMBL395092)
Affinity DataKi:  9.90E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PDE10A2 catalytic domain expressed in Escherichia coli BL21(DE3) RIL cells using 3',5'-cGMP as substrate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)