BDBM50240998 CHEMBL4061315

SMILES c1cc(sc1)C(=O)Nc2cc(c(cc2F)F)Nc3ccc4c(c3)CCc5ccc(cc5C4=O)C(=O)NCCN6CCOCC6

InChI Key InChIKey=KAMAPKIQUKEGQC-UHFFFAOYSA-N

Data  2 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50240998   

TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50240998(CHEMBL4061315)
Affinity DataKd:  4.40nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50240998(CHEMBL4061315)
Affinity DataIC50: 1nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50240998(CHEMBL4061315)
Affinity DataKd:  2.70nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells assessed as dissociation rate consta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50240998(CHEMBL4061315)
Affinity DataIC50: 43nMAssay Description:Inhibition of P38 alpha MAPK in human whole blood assessed as reduction in TNF-alpha release after 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)