BDBM50240868 7-Hydroxy-8-(3-methyl-but-2-enyl)-chromen-2-one::CHEMBL350475::OSTHENOL

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])ccc2ccc(=O)oc12

InChI Key InChIKey=BNBGJXOIZNRLJJ-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50240868   

TargetBeta-secretase 1(Human)
Kinki University

Curated by ChEMBL
LigandPNGBDBM50240868(CHEMBL350475 | 7-Hydroxy-8-(3-methyl-but-2-enyl)-c...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins by fluorescence quenching assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50240868(CHEMBL350475 | 7-Hydroxy-8-(3-methyl-but-2-enyl)-c...)
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50240868(CHEMBL350475 | 7-Hydroxy-8-(3-methyl-but-2-enyl)-c...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophoto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50240868(CHEMBL350475 | 7-Hydroxy-8-(3-methyl-but-2-enyl)-c...)
Affinity DataIC50: 2.53E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50240868(CHEMBL350475 | 7-Hydroxy-8-(3-methyl-but-2-enyl)-c...)
Affinity DataIC50: 740nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by spectrophotom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50240868(CHEMBL350475 | 7-Hydroxy-8-(3-methyl-but-2-enyl)-c...)
Affinity DataKi:  260nMAssay Description:Competitive inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed