BDBM50239489 CHEMBL4100091::US10329302, Example 121::US10793579, Example 122::US11702424, Example 121

SMILES COc1cc2c(ccnc2OC[C@@H]3CCC(=O)N3)cc1C(=O)N

InChI Key InChIKey=DKOZNISSKWTTSU-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50239489   

LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 347nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 7.60nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 7.60nMAssay Description:Protocol B: To begin the assay, 45 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 228 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 24nMAssay Description:Protocol B: To begin the assay, 45 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 228 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 7.60nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of full-length IRAK4 (unknown origin) in presence of ATP by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 347nMAssay Description:Inhibition of IRAK4 in human PBMC cells assessed as reduction in R848-stimulated TNF-alpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)