BDBM50238094 CHEMBL4096361

SMILES Fc1ccc(Cl)cc1-c1cc(Nc2ccnc3cn(CC4CCNCC4)nc23)ccn1

InChI Key InChIKey=QZJHLQYMHQMSIQ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50238094   

TargetTGF-beta receptor type-1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50238094(CHEMBL4096361)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in SBE-bla HEK293T cells assessed as decrease in TGFbeta1-induced Smad2/3 phosphorylation by beta lacta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2019
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50238094(CHEMBL4096361)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant N-terminal GST tagged human ALK5 (200 to 503 residues) expressed in baculovirus expression system using FAM-NH2-KVLTQMGSPSI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2019
Entry Details Article
PubMed