BDBM50236362 CHEMBL429743::N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide::N-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide

SMILES COc1cc2c(ccnc2cc1OC)Oc3ccc4c(c3)cccc4C(=O)Nc5ccc(cc5)Cl

InChI Key InChIKey=WUBFAXNVDMCVIO-UHFFFAOYSA-N

Data  20 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50236362   

TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 371nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
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TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 0.490nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/22/2013
Entry Details Article
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TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetVascular endothelial growth factor receptor 1(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 0.5nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetVascular endothelial growth factor receptor 3(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 38nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetMacrophage colony-stimulating factor 1 receptor(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Inhibition of c-FMSMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetFibroblast growth factor receptor 2(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 55nMAssay Description:Inhibition of FGFR2More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 18nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 38nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 580nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 0.480nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 450nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 0.480nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/29/2012
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 0.0300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetVascular endothelial growth factor receptor 2(Human)
Lanzhou University

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
1/11/2010
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetPlatelet-derived growth factor receptor beta(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL

LigandBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)Copy SMILESCopy InChI

Affinity DataIC50: 18nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL