BDBM50236360 CHEMBL4066708

SMILES Cn1c2ccsc2cc1C(=O)Nc3cccc(c3)COC

InChI Key InChIKey=ZQZRVLFBPXQREF-UHFFFAOYSA-N

Data  1 KI  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50236360   

TargetLysine-specific histone demethylase 2(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236360(CHEMBL4066708)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of KDM1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236360(CHEMBL4066708)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using biotinylated H3K4me1 peptide as substrate preincubated for 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236360(CHEMBL4066708)
Affinity DataIC50: 2.71E+4nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using H3K4me1 peptide as substrate preincubated for 15 mins with e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236360(CHEMBL4066708)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using biotinylated H3K4me1 peptide as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236360(CHEMBL4066708)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236360(CHEMBL4066708)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MAOA incubated for 15 mins measured after 30 mins by luminescence-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2019
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236360(CHEMBL4066708)
Affinity DataIC50: 5.68E+4nMAssay Description:Inhibition of recombinant human MAOB incubated for 15 mins measured after 30 mins by luminescence-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50236360(CHEMBL4066708)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236360(CHEMBL4066708)
Affinity DataKi:  4.30E+4nMAssay Description:Non-competitive inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using H3K4me1 peptide as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)