BDBM50236243 CHEMBL4059930::US11186582, Example 340

SMILES Cc1cc(C2CN(CC(F)(F)C2)C(=O)c2ccc(F)c(I)c2)n2ncnc2n1

InChI Key InChIKey=BCKWAMYDZGLZLN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50236243   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236243(CHEMBL4059930 | US11186582, Example 340)
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236243(CHEMBL4059930 | US11186582, Example 340)
Affinity DataIC50: 100nMAssay Description:An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent