BDBM50234144 1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimidin-4-yl)urea::CHEMBL253292

SMILES CCN(CC)CCOc1ccc(Nc2cc(NC(=O)Nc3c(Cl)cccc3Cl)ncn2)cc1

InChI Key InChIKey=FOMAIMPXVLHOCI-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50234144   

TargetAngiopoietin-1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 300nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 570nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 430nMAssay Description:Inhibition of EphB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 960nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 930nMAssay Description:Inhibition of cKitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cMetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 250nMAssay Description:Inhibition of cABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 380nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 66nMAssay Description:Inhibition of cSrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 570nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Axl kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed