BDBM50233285 CHEMBL4101413

SMILES Cc1cccc2c1nc(cc2)N3CCC(CC3)C(=O)N[C@H]4CCC[C@H]4CCc5ccccc5C(=O)O

InChI Key InChIKey=NLKZRAQTODORFW-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50233285   

TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233285(CHEMBL4101413)
Affinity DataIC50: 6nMAssay Description:Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233285(CHEMBL4101413)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)