BDBM50215552 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile::CHEMBL229429

SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N

InChI Key InChIKey=WTLBLIGPXACYET-UHFFFAOYSA-N

Data  44 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 46 hits for monomerid = 50215552   

TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataIC50: 0.0360nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataIC50: 0.00100nMAssay Description:Activity at human recombinant mGluR5 in CHO cells assessed as inhibition of quisqualate-stimulated phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi:  0.0360nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha-1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to from histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]LSD from 5HT7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]QNB from muscarinic M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]N-methylspiperone from dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity at mGluR6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity at mGluR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]bremazocine from kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cholidine from adrenergic alpha-2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]QNB from muscarinic M5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]N-methylspiperone from dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha-1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to sigma1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]LSD from 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]5-HT from 5HT1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity at mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH-23390 from dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]QNB from muscarinic M3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]pindolol from adrenergic beta-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DADLE from delta opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cholidine from adrenergic alpha-2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]QNB from muscarinic M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]pindolol from adrenergic beta-1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]WIN-35428 from DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]GR-125743 from 5HT1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]LSD from 5HT5A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]N-methylspiperone from dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity at mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of radiolabeled SKF-38393 from dopamine D5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]diprenorphine from mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity at mGluR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]GR-125743 from 5HT1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]LSD from 5HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cholidine from adrenergic alpha2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]nisoxitine from NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]QNB from muscarinic M4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed