BDBM50209748 CHEMBL3884960

SMILES CN1CCN(CC1)c2ccc(cc2)Nc3ncc(c(n3)Oc4ccccc4NC(=O)C=C)Cl

InChI Key InChIKey=WOQNVLPDIGPVKR-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50209748   

TargetMitogen-activated protein kinase 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50209748(CHEMBL3884960)
Affinity DataIC50: 7.89E+3nMAssay Description:Inhibition of full length recombinant human GST-tagged ERK2 expressed in Escherichia coli using Ser/Thr 03 as substrate after 1 hr by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50209748(CHEMBL3884960)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50209748(CHEMBL3884960)
Affinity DataIC50: 78nMAssay Description:Inhibition of full length recombinant human His-tagged MEK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50209748(CHEMBL3884960)
Affinity DataIC50: 360nMAssay Description:Time-dependent inhibition of TAB1 fused TAK1 (unknown origin) using FAM-LRRKtide as substrate by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50209748(CHEMBL3884960)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of TAK1 (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50209748(CHEMBL3884960)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details Article
PubMed