BDBM50208517 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one::CHEMBL222102::KU-55933

SMILES c1ccc2c(c1)Sc3cccc(c3S2)C4=CC(=O)C=C(O4)N5CCOCC5

InChI Key InChIKey=XRKYMMUGXMWDAO-UHFFFAOYSA-N

Data  1 KI  22 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50208517   

TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 13nMAssay Description:Inhibition of ATM (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 250nMAssay Description:Competitive inhibition of ATM (unknown origin) measured by ATP-competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 13nMAssay Description:Inhibition of ATM (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human HeLa nuclear extract derived ATM using glutathioneS-transferase-p53N66 as substrate preincubated for 10 mins followed by ATP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 183nMAssay Description:Inhibition of DNAPK (unknown origin) using p53-based peptide substrate preincubated for 5 min prior to ATP additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged recombinant mTOR (1362 to 2549 residues) (unknown origin) using Biotin-Ahx-Lys-Lys-Ala-Asn-Gln-Val-Phe-Leu-Gly-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant PI3Kgamma using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 133nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 458nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ATR in human HT-29 cells assessed as reduction in Chk1 phosphorylation at Ser-345 residue after 60 mins in presence of 4-nitroquinoline...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of mTOR by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 13nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase ATR(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 300nMAssay Description:Inhibition of ATM kinase in human MCF7 cells after 1 hr by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human ATM using p53 as substrate preincubated for 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 250nMAssay Description:Inhibition of ATM in human U2OS cells assessed as inhibition of p53 phosphorylation at Ser15 residueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 13nMAssay Description:Inhibition of ATM kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of DNA-PK in HeLa cell nuclear extractsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 14nMAssay Description:Inhibition of ATM isolated from human HeLa cell extract using glutathione S-transferase-p53N66 as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of ATMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)