BDBM50206009 CHEMBL3983039::US10280165, Example 35

SMILES CC1=C(N2C(=NC(=CC2=O)Cn3c(cc(n3)C(F)(F)F)Cl)C=C1)[C@@H]4C[C@H]4C#N

InChI Key InChIKey=PXLJMGCNGCDJTO-UHFFFAOYSA-N

Data  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50206009   

TargetGlutamate receptor 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50206009(CHEMBL3983039 | US10280165, Example 35)
Affinity DataEC50:  3.10E+4nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50206009(CHEMBL3983039 | US10280165, Example 35)
Affinity DataEC50:  3.10E+4nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50206009(CHEMBL3983039 | US10280165, Example 35)
Affinity DataEC50:  41nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50206009(CHEMBL3983039 | US10280165, Example 35)
Affinity DataEC50:  77nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)