BDBM50205841 CHEMBL3898956

SMILES C[C@@H]1CC(=O)Nc2ccc(c(c2)CN(C(=O)[C@@H](c3ccc(c1c3)OCC(F)F)Nc4ccc5c(c4)c(cnc5N)F)C)S(=O)(=O)C6CC6

InChI Key InChIKey=UWAQLEGUXYPPDC-UHFFFAOYSA-N

Data  3 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50205841   

TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50205841(CHEMBL3898956)
Affinity DataKi:  0.240nMAssay Description:Inhibition of recombinant human factor-7a/TF using S2288 as substrate measured after 60 mins at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKallikrein-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50205841(CHEMBL3898956)
Affinity DataKi:  9.40nMAssay Description:Inhibition of tissue Kallikrein-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50205841(CHEMBL3898956)
Affinity DataKi:  39nMAssay Description:Inhibition of activated protein C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed