BDBM50205338 CHEMBL3948237

SMILES CCOc1ccc(cc1)S(=O)(=O)Nc2cc(c(c3c2cccc3)NS(=O)(=O)c4ccc(cc4)OCC)CC(=O)C

InChI Key InChIKey=VUIVGOOWLHGDPZ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50205338   

TargetNuclear factor erythroid 2-related factor 2(Human)
Keio University

Curated by ChEMBL
LigandPNGBDBM50205338(CHEMBL3948237)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of recombinant GST-His-tagged Keap1-DC domain (321 to 609 residues) (unknown origin) expressed in Escherichia coli/FAM-labeled Nrf2 (unkno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50205338(CHEMBL3948237)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of GST/His-tagged human KEAP1 (321 to 609 residues) interaction with phosphorylated p62 expressed in Escherichia coli cells by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50205338(CHEMBL3948237)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of KEAP1/Nrf2 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)