BDBM50203422 CHEMBL3937635

SMILES COc1ccc(cn1)[C@@H](Oc1ccc2n(ncc2c1)-c1ccc(F)cc1)[C@H](C)NC(=O)C1CC1

InChI Key InChIKey=YDRQCGICZKAGCQ-UHFFFAOYSA-N

Data  10 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50203422   

TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to ERalpha (unknown origin) by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2018
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataIC50: 2.00E+4nMAssay Description:Binding affinity to AR (unknown origin) by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2018
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataIC50: 0.400nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2018
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to ERbeta (unknown origin) by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2018
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of 3H-aldosterone from MR (unknown origin) ligand binding domain by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2018
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataIC50: 2.80nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2018
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataIC50: 2.00E+4nMAssay Description:Binding affinity to PR (unknown origin) by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2018
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataIC50: 0.240nMAssay Description:Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataIC50: 6.30nMAssay Description:Displacement of fluormone RED from human full length glucocorticoid receptor after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataIC50: 46nMAssay Description:Transrepression of GR in human whole blood assessed as inhibition of LPS-induced TNF-alpha release preincubated for 45 mins followed by LPS addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)
Affinity DataEC50:  1.30nMAssay Description:Transactivation activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells incubated for 24 hrs by beta-galactosidase repo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed