BDBM50202642 CHEMBL3948584

SMILES CC(C)(C)OC(=O)N1CCC2(CC1)C[C@@H]2CNC(=O)N3Cc4ccncc4C3

InChI Key InChIKey=DLHHFYXNVIMXSY-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50202642   

TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50202642(CHEMBL3948584)
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta (DE3) cells using nicotinamide as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50202642(CHEMBL3948584)
Affinity DataIC50: 1.00E+4nMAssay Description:Reversible inhibition of CYP2C9 in human liver microsomes using (S)-warfarin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2018
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50202642(CHEMBL3948584)
Affinity DataIC50: 1nMAssay Description:Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)