BDBM50195782 CHEMBL3958809

SMILES CC(C)CN([C@H]1C[C@H](CNC1)C(=O)N2CCOCC2)C(=O)c3cnc(nc3NCCCOC)C(C)(C)C

InChI Key InChIKey=ISBMTDVOSWIALV-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50195782   

TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195782(CHEMBL3958809)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human preprorenin expressed in human 293F cells using angiotensinogen as substrate preincubated for 10 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195782(CHEMBL3958809)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of renin in human plasma by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195782(CHEMBL3958809)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of renin in human plasma by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195782(CHEMBL3958809)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of recombinant human renin using angiotensinogen as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195782(CHEMBL3958809)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human renin using angiotensinogen as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)