BDBM50194715 CHEMBL3918580

SMILES Cc1c(cccc1-n1cnc2ccccc2c1=O)-c1ccc(C(O)=N)c2[nH]c3cc(ccc3c12)C(C)(C)O

InChI Key InChIKey=TVJRDCQUZMGBAB-UHFFFAOYSA-N

Data  45 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 50194715   

TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 150nMAssay Description:Inhibition of partial length human LCK expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of BTK in mouse whole blood assessed as suppression of BCR/anti-IgM stimulated CD69 surface expression on B cells after 18 hrs by FACS ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human liver microsomes CYP1A2 after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human liver microsomes CYP2B6 after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human liver microsomes CYP2C8 after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 26nMAssay Description:Inhibition of BTK in human RamosB cells assessed as suppression of BCR/anti-IgM stimulated calcium flux pre-incubated for 1 hr followed by BCR/anti-I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 30nMAssay Description:Inhibition of partial length human TRKA expressed in mammalian systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 370nMAssay Description:Inhibition of partial length human JAK2 expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human liver microsomes CYP2D6 after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 3.19E+3nMAssay Description:Inhibition of partial length human SRC expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 13nMAssay Description:Inhibition of partial length human TEC expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 180nMAssay Description:Inhibition of partial length human TXK expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 14nMAssay Description:Inhibition of BTK in human PBMC assessed as suppression of FCgamma2aR/FCgamma3R stimulated TNFalpha production after 7 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 8nMAssay Description:Inhibition of BTK in human peripheral B cells assessed as suppression of BCR/anti-IgM/IgG stimulated CD69 surface expression after 18 hrs by FACS ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human liver microsomes CYP2C9 after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human liver microsomes CYP3A4 after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 40nMAssay Description:Inhibition of BTK in human peripheral B cells assessed as reduction in anti-IgM/IgG-induced CD86 surface expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK in human peripheral B cells assessed as reduction in CD40/CD40L-induced CD86 surface expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 14nMAssay Description:Inhibition of BTK in human PBMC cells assessed as inhibition of FCepsilonR1/immune complex-induced TNFalpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of BTK in mouse whole blood assessed as reduction in anti-IgM/IgG-induced CD69 surface expression on peripheral B cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full-length His-tagged human BTK expressed in baculovirus expression system using fluoresceinated peptide as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 26nMAssay Description:Inhibition of BTK in human Ramos B cells assessed as reduction in goat anti human IgM-stimulated calcium flux preincubated for 1 hr followed by goat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 550nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in goat anti human IgM/human IL4-stimulated CD69 cell surface expression on peripheral B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged full length human recombinant BTK expressed in baculovirus using fluoresceinated peptide substrate after 60 mins by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK in human peripheral B cells assessed as suppression of CD40/CD40L-stimulated CD69 surface expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 550nMAssay Description:Inhibition of BTK in human whole blood assessed as suppression of BCR/anti-IgM/IgG-stimulated CD69 surface expression after 18 hrs with agitation by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 8nMAssay Description:Inhibition of BTK in human peripheral B cells assessed as suppression of BCR/anti-IgM/IgG-stimulated cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 14nMAssay Description:Inhibition of BTK in human PBM cells assessed as suppression of FCRgammaR/immune complex-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of BTK in mouse whole blood assessed as suppression of BCR/anti-IgM/IgG-stimulated CD69 surface expression after 18 hrs with agitation by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 30nMAssay Description:Inhibition of BTK in human Ramos-B cells assessed as suppression of BCR/anti-IgG-stimulated Ca2+ flux after 1 hr incubation in dark by FLIPR1 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 40nMAssay Description:Inhibition of BTK in human peripheral B cells assessed as suppression of BCR/anti-IgM/IgG-stimulated CD86 surface expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 26nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in intracellular calcium level incubated for 1 hr measured for 180 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human full-length His-tagged BTK cytoplasmic domain expressed in baculovirus expression system using fluorescence-labelled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 550nMAssay Description:Inhibition of BTK in human whole blood assessed as suppression of BCR/anti-IgM stimulated CD69 surface expression on B cells after 18 hrs by FACS ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of full length recombinant human His-tagged BTK expressed in baculovirus using fluoresceinated peptide incubated for 60 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 100nMAssay Description:Inhibition of partial length human TRKB expressed in mammalian systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 24nMAssay Description:Inhibition of full length human BMX expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 96nMAssay Description:Inhibition of partial length human ITK expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 20nMAssay Description:Inhibition of BLK (unknown origin) expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 50nMAssay Description:Inhibition of partial length human HER4 expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 110nMAssay Description:Inhibition of partial length human RET expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 160nMAssay Description:Inhibition of partial length human LYN expressed in bacterial systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 8nMAssay Description:Inhibition of BTK in human tonsillar B cells assessed as suppression of BCR/anti-IgM/IgG stimulated cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50194715(CHEMBL3918580)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK in human peripheral B cells assessed as suppression of CD40/CD40L stimulated CD69 surface expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed