BDBM50192770 CHEMBL3956096

SMILES Cc1cc2ccc1[C@H](COC(=O)Nc3ccc(c(c3)CN(C(=O)[C@@H]2Nc4ccc5c(c4)c(cnc5N)F)C)C6(CCCCC6)C(=O)O)C

InChI Key InChIKey=ONDHAMRPENUPCS-UHFFFAOYSA-N

Data  5 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50192770   

TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192770(CHEMBL3956096)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of recombinant human TF-factor 7a using factor 10 as substrate at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVitamin K-dependent protein C(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192770(CHEMBL3956096)
Affinity DataKi:  155nMAssay Description:Inhibition of activated protein C (unknown origin) at 37 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192770(CHEMBL3956096)
Affinity DataKi:  900nMAssay Description:Inhibition of factor 10a (unknown origin) at 25 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192770(CHEMBL3956096)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human kallikrein1 at 37 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192770(CHEMBL3956096)
Affinity DataKi: >1.33E+4nMAssay Description:Inhibition of thrombin (unknown origin) at 25 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed